The deadly US aggression was carried out in a crowded market in the al-Farwa neighborhood in the Sha'ub district on Monday morning.
The death toll is expected to rise as many people are still trapped under the rubble of buildings destroyed in the attack.
Other parts of Sana’a, including the Attan area and al-Wahda District, were also the scene of violent American airstrikes.
Separately, US strikes targeted areas in the Sa’ada governorate, in the country’s far north, the central governorate of Ma’rib, and Hudaydah in the west.
On Sunday, several US air attacks were carried out in Yemen, including strikes on Sana’a, killing at least three.
Yemen’s al-Masirah television channel, citing a statement by the Ministry of Public Health and Population, announced that the US military launched 21 airstrikes on Sana’a as well as its western, eastern, and southern outskirts on Saturday night.
The US military has been carrying out almost daily attacks on Yemen for the past month, claiming that they are aimed at stopping the Ansarullah movement’s attacks on Israel-related ships.
The Yemeni army, however, said it will not stop its attacks on Israel-bound vessels until the regime halts its Gaza aggression.
Press TV